Low Grade Inflammation and Cardiovascular Disease Risk among First Degree Relatives of Persons with Type 2 Diabetes Mellitus in a Northern Nigerian Population

  • Y Lawal Federal Medical Centre Azare, Bauchi state
  • F Bello Department of Internal Medicine, Ahmadu Bello University Teaching Hospital Zaria
  • FE Anumah College of Health Sciences, University of Abuja Teaching Hospital, Gwagwalada, Abuja
  • AG Bakari College of Health Sciences, Ahmadu Bello University Teaching Hospital Zaria
Keywords: Cardiovascular diseases, Diabetes mellitus, First degree relative, High sensitivity C-reactive protein, Inflammation

Abstract

Low grade or subclinical inflammation has been reported in various literatures as a marker, predictor, or pathogenetic factor in the development of cardiovascular diseases (CVD) and type 2 diabetes mellitus.The risk factors for the development of type 2 diabetes mellitus (DM) have been broadly classified into environmental and genetic factors. First degree relatives (FDR) of persons with type 2 DM (FDRs) are most likely to have inherited genes that will predispose them to diabetes. Does it mean that these FDRs will also have genetic susceptibility to cardiovascular diseases? We aimed to assess low grade inflammation/CVD risk in FDRs and to determine whether FDR status, obesity indices, blood pressure levels, and plasma glucose levels are independent risk factors for low grade inflammation and CVD risk. First degree relatives of persons with type 2 diabetes and controls were recruited from their respective communities after due consent. Relevant biodata were documented and appropriate examinations including anthropometric measurements were carried out. Laboratory investigations (plasma glucose levels and high sensitivity C-reactive protein (hsCRP) were subsequently done. Out of a total of 35.4% of participants that fell under the ‘high’ CVD risk category, FDRs and controls constituted 24.7% and 10.6% respectively. Logistic regression analysis showed that significant independent determinants of low grade inflammation and CVD risk included FDR status, smoking, some obesity indices, and elevated plasma glucose levels.

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Author Biographies

F Bello, Department of Internal Medicine, Ahmadu Bello University Teaching Hospital Zaria

Consultant Endocrinologist and associate professor of Medicine 

Department of Internal Medicine 

FE Anumah, College of Health Sciences, University of Abuja Teaching Hospital, Gwagwalada, Abuja

Consultant Endocrinologist and Professor of Endocrinology, 

Department of Internal Medicine 

AG Bakari, College of Health Sciences, Ahmadu Bello University Teaching Hospital Zaria

Consultant Endocrinologist and Professor of Endocrinology 

Department of Internal Medicine 

Published
2019-07-20
How to Cite
Lawal, Y., Bello, F., Anumah, F., & Bakari, A. (2019). Low Grade Inflammation and Cardiovascular Disease Risk among First Degree Relatives of Persons with Type 2 Diabetes Mellitus in a Northern Nigerian Population. JOURNAL OF RESEARCH IN BASIC AND CLINICAL SCIENCES, 1(2), 190-196. Retrieved from https://chsjournal.org.ng/index.php/jrbcs/article/view/23