Update on Clinical Evaluation and Management of Organophosphate Poisoning

  • AF Asalu Department of Pharmacology & Therapeutics College of Health Sciences, Benue State University Makurdi, Benue State
  • J Oloche Department of Pharmacology & Therapeutics, Benue State University Makurdi, Nigeria
  • SO Itodo Department of Pharmacology & Therapeutics College of Health Sciences, Benue State University Makurdi, Benue State
  • PO Arubi Department of Pharmacology & Therapeutics College of Health Sciences, Benue State University Makurdi, Benue State
Keywords: Acetylcholinesterase, Poisoning, Acetylcholine, Atropine, Organophosphates

Abstract

Exposure to Organophosphates (OPs) and Poisonings are common and account for significant morbidity and mortality, especially resource-poor countries. This is due to the uncontrolled sale and indiscriminate domestic and agricultural use of these compounds and their derivatives. Unintentional and self-poisoning occurring from these compounds is therefore not uncommon. The paucity of knowledge in clinical settings on the evaluation, diagnosis and case management of conditions associated OPs poisoning necessitated this review in order to provide adequate and clinically relevant information to healthcare professionals. A detailed literature search was carried out using keywords related to manifestations, diagnosis and management of organophosphate poisoning. Manifestations of poisonings are mainly those related to cholinergic activity. Even in the absence of facilities to assay cholinesterase tools, utility tools such as APACHE II and Glasgow coma scale can be used along with clinical manifestations to stage severity and predict outcome. Prompt recognition of Poisonings, immediate institution of resuscitative measures and administration of appropriate agents such as Atropine and Oximes are essential for satisfactory outcomes.

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Published
2019-07-20
How to Cite
Asalu, A., Oloche, J., Itodo, S., & Arubi, P. (2019). Update on Clinical Evaluation and Management of Organophosphate Poisoning. JOURNAL OF RESEARCH IN BASIC AND CLINICAL SCIENCES, 1(2), 116-121. Retrieved from https://chsjournal.org.ng/index.php/jrbcs/article/view/42